RESUMO
Ð cross-sectional study was performed on a continuous sample of patients (N=52) with the gastroesophageal reflux disease. Specific features of this disease in patients with overweight were revealed. Regurgitation predominated in the structure of complaints. Fibrogastroduodenoscopy revealed endoscopically negative form of the diseases in 38% of cases. According to 24-h pH monitoring results, alkaline reflux pH>7 took more than 25% time in supine position at high DeMeester score, which limits the usage of aggressive acid-lowering therapy.
Assuntos
Refluxo Gastroesofágico/complicações , Refluxo Gastroesofágico/epidemiologia , Sobrepeso/complicações , Sobrepeso/epidemiologia , Adulto , Índice de Massa Corporal , Estudos Transversais , Endoscopia Gastrointestinal , Esôfago/metabolismo , Esôfago/patologia , Feminino , Refluxo Gastroesofágico/diagnóstico , Refluxo Gastroesofágico/terapia , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Sobrepeso/diagnóstico , Sobrepeso/terapia , Medicina de Precisão , Índice de Gravidade de Doença , Adulto JovemRESUMO
JAK/STAT signaling pathway was examined during functional stimulation of mesenchymal progenitor cells with fibroblast growth factor. The differences were observed in the realizations of the proliferation-differentiation potential of CFU-fibroblasts under blockade of JAKs or during selective inactivation of STAT3. The study revealed stimulating influences of JAKs and STAT3 on mitotic activity of progenitor cells and individual roles of these proteins in the control of their maturation. Blockade of JAKs diminished the level of fibroblast colony formation and the score of actively proliferating CFU-fibroblasts at the background increase of the differentiation rate of progenitor cells. In contrast, STAT3 inhibitor resulted in a coordinated decrease of all examined parameters.
